Phytochemical Investigation of Uvaria Scheffleri Aerial Parts for Antiplasmodial and Antimicrobial Compounds

Malaria is a major disease worldwide and very prevalent in tropical and subtropical regions. It is caused by protozoan parasites of the genus Plasmodium with P. falciparum being the most lethal. More than 300 million cases arise annually out of which one million deaths occur. Relentless increase in the rate of malaria morbidity and mortality is contributed by emergence of drug resistant strains of Plasmodium falciparum besides poverty and inadequate healthcare systems. Traditional remedies have been used to combat malaria and other diseases caused by microbial infections. Infections caused by viruses, bacteria, fungi and other microbes have developed resistance towards drugs used to eradicate them. The consequences of increased drug resistance would be increased morbidity, greater risks of complications and higher rates of mortality. These would have negative effect on the economy due to increase in the cost of diagnosis and treatment and also loss of productivity.

In an effort to address challenges of resistance towards antiplasmodial and antimicrobial drugs has prompted the analysis of Uvaria schefflerri aerial parts for antimicrobial and anplasmodial principles. In the study, 1:1 DCM/MeOH extraction of the leaves and stem was carried out and the extracts subjected to chromatographic separations. This led to isolation of four compounds DOS01-DOS06.

The structures of these compounds were determined using NMR (1H, 13C, COSY, HMQC, and HMBC) and MS spectroscopy. Compound DOS02 was determined as 5-hydroxy-6,7-dimethoxyflavanone (1) while structure elucidation of the other three compounds is still underway. Bioassay of all the compounds is still being done
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