Anti-Oxidant Tablets from the Leaf Exudate of Dodonaea Angustifolia

Our bodies are comprised of billions of molecular cells held together be electronic bonds. Sometimes these molecules are held together by weak bonds and split apart resulting in an unstable molecule with an unpaired electron. This molecule is known as a free radical. Some free radicals occur normally in our bodies through metabolism. However, there are many environmental factors that can lead to an excess of free radicals such as pollution, radiation, cigarette smoke and herbicides. In addition, stress, lack of exercise and lack of sleep. These free radicals will start attacking healthy nearby cells in an attempt to replace the missing electron. When the attacked molecule loses its electron, it becomes a free radical itself. This can cause a chain reaction to occur resulting in destruction of millions of nearby cells. This chain reaction is known as oxidative stress and many experts agree that it is thought to be the leading cause for arthritis, premature aging, edema and leg swelling, artery hardening and cancer susceptibility. Well, if the destructive process is oxidation, then the answer is anti-oxidation and this is achieved by anti-oxidants. Anti-oxidants stop the chain reaction by donating one of their own electrons to the free radicals.

Flavanoids are intrinsically anti-oxidant as they are phenolic. Dodonaea angustifolia is a stomachic herbal which is widespred in Kenyan 47 counties.It is known that it has a leaf exudate that is rich in non-polar flavonoids. These flavonoids have been determined to have radical scavenging activity as determined by DPPH assay. This assay is a good indicator for anti-oxidant activity. In this project the leaf exudate of the plant was extracted, purified, mixed with excipients and tableted to make an anti-oxidant drug that can be administered for its protective effect.

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