Phytochemical Investigation of the Bark of Millettia usaramensis Subspecies usaramensis

The family Fabaceae is sub- divided into three classes including; Caesalpinoideae, Papilionoideae and Mimosoideae and is the third largest family of flowering plants with about 20,000 species in 650 genera. The genus Millettia belong to the sub- family Papilionoideae known as a source of flavonoids and isoflavonoids. These compounds exhibit different biological activities including anti-inflammatory,anti-microbial and anti-malarial. In this research anti-malarial activity was investigated of the crude extract from the stem bark of Millettia usaramensis.


The crushed and dried stem bark of Millettia usaramensis was exhaustively extracted using CH2CI/MeOH (1:1) at room temperature by percolation. The extract was subggjected tochromatography that led to isolation of four compounds. These compounds included three rotenoids and one isoflavonoid namely: 12a-EpimillettosinUsararotenoid-A  ;  12-Dihyrousararotenoid-A and Jamaicin.

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