Synthesis of Chalcones, Conventionally and using a Green Method and a Few Hydrazine Derivatives




Chalcones are aromatic ketones that show antifungal, antitumor, antibacterial and anti-inflammatory properties. They also form the central core for an important array of compounds collectively known as chalconoids.


In this study a chalcone was prepared by an aldol condensation reaction between benzaldehyde and acetophenone in the presence of sodium hydroxide. This was done in a solvent (ethanol) and a solvent free environment by grinding in a mortar a mixture benzaldehyde, acetophenone and sodium hydroxide pellets.


The chalcone was derivatized using hydrazine hydrate into a pyrazoline derivative using two different methods. The first one involved by refluxing the mixture for 15 hours in a protic polar solvent (ethanol) and separating the product using column chromatography. The second method involved using a polar aprotic solvent, dimethyl sulfoxide (DMSO) at room temperature for 5 minutes. Structures of all products were determined using data from 1H and 13C NMR.

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