Alkaloids from the Stem Bark of Erythrina brucei






In this study, the alkaloidal constituents of the stem bark of Erythrina brucei (Fabaceae family) were extracted, isolated and characterized. The dried and ground stem bark of Erythrina brucei was extracted thrice with dichloromethane and methanol in the ratio of 1:1 by cold percolation for 24 hours at room temperature. The extract was then concentrated using a Rotary Evaporator. The residue was fractionated in a column chromatography. The fractions obtained were further separated using Thin Layer Chromatography (TLC) plates. The compounds were then isolated using Preparative TLC plates.


 Four alkaloids were isolated from the stem bark of this plant of which one is a new alkaloid and named erythbrucein.The other compounds were identified as erythraline, crystamidine and 8-oxo-erythraline.1HNMR and 13CNMR spectroscopic methods were used for structural elucidation of these isolated compounds. Alkaloids commonly occur in the seeds and flowers of erythrina species. This is the second report on the occurrence of alkaloids in the stem bark.

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